Epigenetics. 2nd edition

In many biological processes, the regulation of genes expression includes epigenetic mechanisms. The new edition of Epigenetics in 36 chapters written by leading specialists in this field describes, explain and discusses diverse epigenetic effects. The book presents various molecular mechanisms that underlie epigenetic regulation, discuss cell processes that depend on this kind of regulation, and an overview of model organisms is given, in which the epigenetic effects are most studied. All chapters of the previous publication are actualized, new chapters containing information about the structure, function and dynamics of histone-modification enzymes and histone-imperial proteins are also added. Certain chapters of this book are devoted to chromatin remodeling, DNA methylation, small interfering RNA and repression (silencing) of genes; inactivation of x chromosome, dose compensation and imprinting; The epigenetics of mushrooms, plants, insects and mammals. The book considers how epigenetic mechanisms are involved in cellular division and specifications of the cell type and how epigenetic disorders affect the development of cancer and other human diseases. In addition, the significance of epigenetics for induced pluripotence and cell reprogramming is considered. The new chapters of this publication describe the participation of epigenetic processes in the inheritance, development of neurons, metabolism and alarm, reactions of cells to the environment, as well as distant chromatin interactions, and a series of short essays illuminates important modern discoveries. The book contains original illustrations that will help readers understand the mechanisms of epigenetic control. The book can be a manual to study genes for students and graduate students of senior courses, as well as the necessary resource for scientists interested in this rapidly developing field.