Preclinical studies of medicinal substances. Tutorial. Buzlam A.V.

The manual contains scientifically sound information necessary for the beginner experimenter for planning and conducting preclinical studies of drugs. The main methodological techniques of experimental work with laboratory animals are described, including information about modern latest devices and devices. Given the authors' own scientific areas of the authors presented the characteristics of classic models for assessing psychotropic and adaptogenic properties, analgesic, anti -inflammatory and regenerative activity, models of liver damage, experimental diabetes. Particular attention is paid to the characterization of methods for studying the microcirculatory channel, including intravital biomicroscopy. The description of some original copyright developments protected by patents of the Russian Federation (measuring and fixing devices, devices for biomicroscopy, original models and methods).

The publication is intended for graduate students, students performing graduate qualification work, scientific and pedagogical workers, doctors, and will also be useful to a wide range of specialists in the field of biology, chemistry and pharmacy, conducting research using experimental models on laboratory animals.